Author: pressadvantage

  • Mindmachines.com Advances Meditation Technology with Third Generation ROSHIwave Device

    Mindmachines.com Advances Meditation Technology with Third Generation ROSHIwave Device

    Mindmachines.com has released the third generation of its ROSHIwave IN-SIGHT Mind Machine, a brainwave entrainment device that guides users to deep meditative states through advanced photostimulation technology. The updated meditation device incorporates enhanced protocols and improved navigation features designed to help users achieve mental clarity and better performance.

    The ROSHIwave IN-SIGHT represents the culmination of decades of research in brainwave entrainment technology. The pocket-sized device utilizes a process called Dynamic Neuro-Activation, which employs specially calibrated flickering light patterns delivered through RGB LED glasses to normalize brainwave frequencies. This technology enables users to reach meditative states typically associated with experienced Zen practitioners, often within 15-minute sessions.

    meditation device

    “The third generation ROSHIwave builds upon our established protocols while introducing multiplexed versions that provide users with more comprehensive brainwave optimization options,” said Fred Williams, Director of Product Development at Mindmachines.com. “This device serves as what we call a digital compass for the brain, guiding users to achieve mental states that traditionally required years of meditation practice.”

    The updated device features USB rechargeability and operates with an intuitive click-wheel interface similar to portable media players, eliminating the need for smartphone apps or complex setup procedures. The system includes the ROSHIwave Console, color-changing RGB RoshiGlasses with six side-firing LEDs per eye, a Ganzfeld RoshiVisor for immersive light experiences, and a carrying case for portability.

    Nearly 100 clinicians worldwide currently utilize ROSHIwave technology as a therapeutic tool for various applications including stress management, enhanced learning, and behavioral modification. The device employs Brainwave DisEntrainment through Photostimulation, a methodology that differs from traditional entrainment by freeing the mind from repetitive patterns rather than synchronizing to specific frequencies.

    The third-generation model incorporates the pROSHI 2++ protocols, developed by the late Chuck Davis, a pioneer in brainwave entrainment research. These protocols expand the device’s capabilities for addressing various mental states and performance goals. The technology has applications in education, biofeedback therapy, stress reduction, and personal wellness programs.

    While not classified as a medical device, the ROSHIwave IN-SIGHT has garnered attention from wellness practitioners and performance coaches seeking non-invasive methods to help clients achieve optimal mental states. The device includes safety features and clear guidelines, with specific warnings against use by individuals with seizure disorders.

    The release of this third-generation device comes as interest in technological meditation aids continues to grow among both wellness professionals and individuals seeking alternatives to traditional meditation practices. The ROSHIwave technology represents an intersection of neuroscience research and practical application in the field of consciousness exploration and mental performance optimization.

    Mindmachines.com serves as a global distributor of brain machines, brainwave entrainment technology, AVS stimulation devices, EEG neurofeedback equipment, and meditation machines. The company, operated by Av3X LLC and based in Dallas, Texas, specializes in technologies designed to enhance mental performance, wellness, and personal achievement through advanced brainwave modulation techniques.

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    For more information about Mindmachines.com, contact the company here:

    Mindmachines.com
    Fred Williams
    orders@mindmachines.com
    www.mindmachines.com

  • Century Pools Reveals Most Popular Inground Pool Design Requests

    Century Pools Reveals Most Popular Inground Pool Design Requests

    Century Pools, the Northern California pool construction specialist serving the region since 1964, announced findings from their annual design trend analysis, revealing the most popular inground pool styles requested by local homeowners throughout 2024. The family-owned company has compiled data from hundreds of consultations and projects to identify emerging preferences in residential pool design.

    The analysis shows a marked shift toward multifunctional pool designs that blend aesthetic appeal with practical features. Geometric pools with integrated spa combinations have emerged as the leading choice, representing nearly 40 percent of all design requests. These versatile installations allow homeowners to maximize their outdoor living spaces while accommodating both relaxation and entertainment needs.

    Freeform pools maintaining natural, organic shapes have secured the second position in popularity, particularly among properties with existing landscape features. Homeowners are increasingly requesting designs that complement native California terrain and drought-resistant landscaping, reflecting growing environmental consciousness in pool construction choices.

    “The trend data reveals homeowners are thinking beyond traditional rectangular pools and embracing designs that serve as complete outdoor living solutions,” said Patrick O’Neal, a representative at Century Pools. “We’re seeing sophisticated requests for infinity edges, variable depth zones, and integrated lighting systems that transform pools into architectural centerpieces that enhance property values while providing year-round enjoyment in Northern California’s favorable climate.”

    The company’s findings also indicate rising interest in sustainable pool technologies. Solar heating systems and energy-efficient variable-speed pumps have become standard inclusions in most new installations, with homeowners prioritizing long-term operational efficiency alongside initial design considerations.

    Lap pools designed for fitness enthusiasts have shown steady growth, particularly in smaller residential lots where space optimization is crucial. These streamlined designs demonstrate how modern pool construction can accommodate specific lifestyle needs without compromising on quality or visual appeal.

    As an experienced inground pool builder, Century Pools has observed that customization requests have become increasingly sophisticated. Homeowners now arrive at consultations with detailed vision boards and specific feature requirements, from beach entries and tanning ledges to automated covers and smart pool management systems.

    The trend analysis also highlights the importance of professional design consultation in achieving optimal results. Many homeowners initially underestimate factors such as ground composition, drainage requirements, and maintenance accessibility, elements that significantly impact long-term satisfaction with their investment.

    Century Pools maintains an A+ rating with the Better Business Bureau and has established itself as a resource for pool construction throughout Northern California. The company specializes in various pool types, including gunite, geometric, and freeform designs, offering comprehensive services from initial consultation through installation and ongoing maintenance support. Their team of certified technicians and designers work closely with clients to develop customized solutions that align with individual preferences, property characteristics, and budget considerations while adhering to all local building codes and safety regulations.

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    For more information about Century Pools, contact the company here:

    Century Pools
    Patrick O’Neal
    (916) 989-1995
    centurypoolsov@gmail.com
    8788 Greenback Ln #101, Orangevale, CA 95662

  • WhiteSands Treatment in Orlando Publishes New Resource on Treating Addiction and Mental Health Together

    ORLANDO, FL September 18, 2025 – PRESSADVANTAGE –

    Orlando- WhiteSands Treatment in Orlando has published a new article exploring how addiction and mental health are interconnected and why addressing both is essential for long-term recovery. The piece, titled “How Is Addiction and Mental Health Treated?”, emphasizes the growing recognition that co-occurring disorders must be treated together to achieve lasting sobriety and emotional stability.

    As one of Orlando’s leading addiction treatment centers, WhiteSands has established a reputation for comprehensive recovery programs that address both substance use and mental health conditions. The Orlando location offers a full continuum of care, including inpatient alcohol and drug rehab, medical detox, outpatient services, IOP, and PHP. This integrated approach combines evidence-based therapy with holistic practices, focusing on both the physical and psychological components of recovery.

    WhiteSands Full Continuum of Care Across Florida Addiction Treatment Center Locations

    The Orlando facility is positioned to serve not only the city itself but also surrounding high-profile neighborhoods and communities such as Winter Park, Doctor Phillips, Windermere, Lake Nona, and Baldwin Park. These areas, known for their professional and family-centered populations, represent a broad cross-section of the people who turn to WhiteSands for treatment. By tailoring care to the unique needs of each patient, the center provides structured support that helps people return to daily life with greater resilience and stability.

    The new article underscores the reality that addiction rarely occurs in isolation. Conditions such as depression, anxiety, or trauma often play a role in fueling substance use, and without addressing these underlying factors, relapse remains a significant risk. By integrating addiction treatment with mental health care, WhiteSands Orlando delivers a model of recovery that equips patients with long-term strategies for both sobriety and emotional well-being.

    WhiteSands Treatment has consistently been recognized as one of the nation’s top-rated addiction treatment providers by Newsweek, reflecting its ongoing commitment to clinical excellence and patient-centered care. This recognition underscores the facility’s position as a trusted resource for people and families throughout Orlando and Central Florida.

    WhiteSands’ national recognition has further distinguished the Orlando facility as a trusted leader in addiction treatment. For five consecutive years, the organization has been named among the top-rated addiction treatment centers in the United States by Newsweek. This award is based on a rigorous methodology that evaluates quality of care, reputation, and patient satisfaction, underscoring the consistency of WhiteSands’ clinical standards across its network of Florida locations.

    The Newsweek accolade reflects more than reputation alone—it highlights WhiteSands’ ability to maintain excellence in a field where standards of care can vary significantly. By combining medical expertise, therapeutic innovation, and a patient-centered philosophy, WhiteSands has earned credibility among both healthcare professionals and the communities it serves. In Orlando, this recognition reinforces the confidence of people and families who are making critical decisions about treatment options.

    The repeated honor also demonstrates that WhiteSands has been able to adapt to changing needs in behavioral healthcare while staying committed to evidence-based practices. Each year, the center’s inclusion on Newsweek’s list confirms its role as a benchmark for addiction and mental health treatment in Florida. For patients, this national distinction provides reassurance that they are entering a program recognized for quality and results, lending further weight to the comprehensive recovery model offered at WhiteSands Orlando.

    For those in Orlando, Winter Park, Windermere, and surrounding communities searching for effective Orlando drug rehab or alcohol rehab options, WhiteSands Treatment provides access to care that emphasizes both recovery and mental health. The newly published article offers additional insight into how this integrated model is shaping better outcomes for people seeking lasting change.

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    For more information about WhiteSands Alcohol & Drug Rehab Orlando, contact the company here:

    WhiteSands Alcohol & Drug Rehab Orlando
    Ryan Monesson
    (407) 255-2351
    rmonesson@wstreatment.com
    56 E Pine St, Orlando, FL 32801

  • Zenapet Launches Cat Colostrum Plus to Support Feline Immune, Gut, and Skin Health

    Zenapet Launches Cat Colostrum Plus to Support Feline Immune, Gut, and Skin Health

    Costa Mesa, California September 15, 2025 – PRESSADVANTAGE –

    ZENAPET Cat Colostrum Plus

    NEWPORT BEACH, CA – September 15, 2025 – Zenapet, a brand committed to providing 100% human-grade, premium pet supplements, today announced the official launch of its new Cat Colostrum Plus Superfood Supplement. The powdered daily mix-in product is specifically designed to support feline immune health, promote gut balance, and help maintain healthy skin and coat. This launch marks a significant strategic expansion for Zenapet within the high-growth feline wellness market, directly addressing the unique nutritional needs of cats.

    The Cat Colostrum Plus formula blends a comprehensive spectrum of key superfood ingredients, each carefully selected for its specific health benefits. The primary components include Bovine Colostrum, Probiotics, and Shiitake Mushroom Powder, which are combined to help support a cat’s immune function and digestive balance. The product also contains Organic Chicken Bone Broth, which is a natural source of collagen and other nutrients that contribute to a healthy skin and a shiny coat. Furthermore, the addition of Nutritional Yeast and Organic Turkey Tail Mushrooms is intended to provide further support for the immune system and gut health. For overall wellness, the formula incorporates Resveratrol, known for its antioxidant properties, and Spirulina, which aids in detoxification and provides a broad range of vitamins and minerals.

    “This launch is a direct response to the increasing demand from pet parents for specialized, high-quality products that address the unique health needs of cats,” stated Casey Dawson, Head of Product Development at Zenapet. “Over the years, our customers have shared stories of their cats’ positive responses to our dog products, inspiring us to create a dedicated line. We have crafted a product that delivers the core benefits of colostrum and other superfood ingredients without any of the fillers or artificial additives commonly found in other supplements, ensuring peace of mind for cat owners.”

    In line with the brand’s core philosophy, the Cat Colostrum Plus is a powdered supplement that easily mixes into a cat’s daily meals. This delivery format ensures a high-potency, easily digestible solution, reinforcing Zenapet’s commitment to purity and transparency. This powder is also easily adopted by even picky eaters, making daily wellness support simple for every cat in the family. The flexible dosing also allows it to be suitable for felines of all breeds, sizes, and ages. Zenapet’s products are manufactured in GMP-certified facilities in the United States, adhering to the highest quality standards.

    Zenapet’s commitment to quality is evident in this new Zenapet Cat Colostrum Supplement, offering a reliable, science-backed solution for cat parents. The product aligns with the growing trend of pet humanization, where owners are increasingly willing to spend on premium, health-focused products to ensure the longevity and quality of life for their pets. By offering a clean, effective, and transparent product, Zenapet continues to position itself as a trusted leader in the rapidly evolving pet wellness industry. For more information on the new supplement and the benefits of feline wellness, visit Zenapet.com or their storefront on Amazon.

    About Zenapet

    Established in 2015, Zenapet is a provider of 100% human-grade, premium superfood-based powdered supplements for dogs and cats. The brand’s mission is to offer pet owners a pure and potent alternative to traditional supplements, focusing on clean, effective, and easily digestible formulations for optimal pet wellness.

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    For more information about Zenapet, contact the company here:

    Zenapet
    Caren Collins
    info@zenapet.com

  • Stocktwits and Polymarket Join Forces: The World’s Largest Prediction Market and the World’s Largest Social Platform for Finance Launch New Earnings Markets

    Stocktwits and Polymarket Join Forces: The World’s Largest Prediction Market and the World’s Largest Social Platform for Finance Launch New Earnings Markets

    New York, New York – September 15, 2025 – (PRESS ADVANTAGE) –

    Polymarket, the world’s largest prediction market platform, and Stocktwits, the largest social platform for investors and traders, today announced a strategic partnership to integrate real-time probabilities on market-moving events directly into the Stocktwits experience, starting with earnings markets for widely followed companies. Polymarket becomes the Official Prediction Markets partner for Stocktwits, a milestone deal that represents the company’s largest-ever strategic partnership.

    The collaboration brings together two of the most dynamic platforms in trading, speculation and investing to deliver what investors want most: transparent, continuously priced expectations around the events that move markets. For the first time, Stocktwits’ 10 million–strong community will be able to see Polymarket’s real-time, crowd-priced probabilities alongside the conversations they’re already having about earnings, sentiment, and market moves, resulting in a streamlined path to act on these views on Polymarket.

    “Prediction markets transform uncertainty into clarity by turning big questions—like earnings—into simple, tradable outcomes with transparent pricing,” said Matthew Modabber, Chief Marketing Officer at Polymarket. “Partnering with Stocktwits allows us to put that power directly into the hands of millions of investors where they already live and engage, reshaping how markets process information.”

    Earnings season has long been one of the most consequential and volatile times for investors. Prediction markets transform these moments into simple, tradable questions with transparent pricing (e.g., Will $TSLA beat earnings?). By surfacing probabilities that update second by second, the integration gives investors a clean, continuously calibrated signal on expectations, helping them sharpen conviction with clarity.

    The partnership will debut with embedded earnings outcome markets on Stocktwits ticker pages and streams, covering select companies during earnings season. Additional experiences include “mention markets” tracking whether specific terms appear on earnings calls, as well as discovery features such as curated collections and watchlists that highlight upcoming earnings with live probabilities. Probabilities will be displayed directly in Stocktwits discussions, with a tap-through to Polymarket for deeper details, order books, and settlement rules. Markets resolve on official company reports/call transcripts per clearly published rules on each Polymarket page. The rollout begins in September 2025 for select U.S. users, with broader availability throughout the earnings season.

    “We are living in a post real-time world where trust, community, and great signals matter more than speed,” said Howard Lindzon, Founder and CEO of Stocktwits. “Polymarket has created an entirely new way to understand news and expectations, and Stocktwits is the place where millions of investors already gather to share ideas and sentiment. Together, we can help investors cut through noise and focus on the probabilities that matter most.”

    Polymarket has recently expanded rapidly, setting records for new market creation, and secured key partnerships and investments, underscoring growing mainstream interest in the world’s largest prediction market.

    Visit Stocktwits.com or polymarket.com/earnings to view live earnings markets and probabilities today.

    About Polymarket

    Polymarket is the world’s largest prediction market platform. It hosts real-time markets on events across business, sports, politics, and more, providing continuously updated probabilities that investors, media, and institutions can reference.

    About Stocktwits

    Stocktwits is the leading social platform for active investors and traders, where millions of market participants connect to discuss markets in real-time. Built on the foundation of social conversation, Stocktwits has grown into a dynamic financial media company where social sentiment uniquely powers original news, video, and editorial coverage spanning equities, crypto, and macro trends. With over 10 million users, Stocktwits empowers investors to track traditional and digital asset sentiment, discover trends, and make informed decisions. Stocktwits’ mission is to help investors improve returns through community, data, content, and the latest tools.

    Media Contact:

    Melrose PR

    stocktwits@melrosepr.com

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    For more information about Stocktwits, contact the company here:

    Stocktwits
    Melrose PR
    stocktwits@melrosepr.com
    228 Park Ave S, Suite #56681
    New York, New York 10003

  • Zenapet Marks 10-Year Anniversary, Reflecting a Decade of Purity in Pet Wellness

    Zenapet Marks 10-Year Anniversary, Reflecting a Decade of Purity in Pet Wellness

    Costa Mesa, California – September 11, 2025 – (PRESS ADVANTAGE) –

    Zenapet Logo

    NEWPORT BEACH, CA – September 12, 2025 – Zenapet, a brand of premium pet supplements founded in 2015, today announced its 10-year anniversary, marking a decade of commitment to providing clean-label nutritional products for dogs and cats. The milestone reflects the company’s long-standing philosophy that pet nutrition should align with the same quality standards as human-grade food. This approach to ingredient purity and formulation has positioned the brand as a consistent voice in the evolving pet wellness market.

    Zenapet’s anniversary coincides with a significant period of growth in the global pet supplements market, driven by a consumer shift toward preventive healthcare and the humanization of pets. For ten years, Zenapet has focused on powdered supplements to avoid fillers, binders, and artificial additives often found in common delivery formats like soft chews. This commitment to purity has become a key differentiator as pet owners increasingly scrutinize product labels and seek transparent, high-quality options for their animals.

    “Our mission from the start has been to create a product line built on premium human-grade ingredients that are both simple and effective,” said Casey Dawson, Head of Product Development at Zenapet. “Every ingredient provides a direct health benefit, and we’re proud to deliver that elevated quality at a price point that remains approachable for pet parents today.”

    Zenapet’s product portfolio includes superfood-based solutions for immune support, joint health, and feline wellness. The company’s products are manufactured in the United States in GMP-certified facilities. Zenapet continues to position itself as a reliable brand that provides transparent, nurtrition-backed solutions to support the well-being of pets.

    About Zenapet

    Established in 2015, Zenapet is a provider of 100% human-grade, premium superfood-based powdered supplements for dogs and cats. The brand’s mission is to offer pet owners a pure and potent alternative to traditional supplements, focusing on clean, effective, and easily digestible formulations for optimal pet wellness.

    Learn more at Zenapet.com or visit Zenapet on Instagram.

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    For more information about Zenapet, contact the company here:

    Zenapet
    Caren Collins
    info@zenapet.com

  • Mellow Sleep Announces Launch of Advanced Cooling Ergonomic Pillow for Side Sleepers

    Mellow Sleep Announces Launch of Advanced Cooling Ergonomic Pillow for Side Sleepers

    Dover, Delaware – September 09, 2025 – (PRESS ADVANTAGE) –

    DOVER, DE – Mellow Sleep, a company focused on sleep ergonomics and material science, today announced the official launch of its new product, the Advanced Cooling Ergonomic Pillow for Side Sleepers. The pillow is engineered to address the physiological needs of this specific sleep profile by combining structural support for spinal alignment with advanced temperature-regulating materials.

    The product’s design was informed by common issues faced by side sleepers, such as the maintenance of a straight spinal posture and thermal discomfort. The Advanced Cooling Ergonomic Pillow for Side Sleepers incorporates a proprietary memory foam, named AdaptiCore™, which is formulated to conform to the user’s head and neck contours. A key design element is the SpineAlign™ Contour, an elevated multi-zone shape intended to fill the space between the head and shoulder, thereby promoting neutral spinal alignment.

    To address temperature regulation, the pillow utilizes FrostFlow™ Cooling Technology. This system combines a gel-infused, open-cell foam with a heat-dissipating fabric cover. The integrated components are designed to manage thermal buildup and maintain a more consistent temperature at the sleep surface.

    “The development of this pillow was driven by direct feedback from consumers regarding the challenges in achieving restorative sleep,” stated Jay Yue, founder of Mellow Sleep. “Our research and development process focused on applying material science to solve the distinct needs for both biomechanical support and temperature regulation. The launch of the Advanced Cooling Ergonomic Pillow for Side Sleepers represents our company’s commitment to creating research-driven solutions for prevalent sleep issues.”

    The pillow includes a removable, machine-washable cover that is OEKO-TEX® Certified, indicating it has been tested for harmful substances. Additionally, it contains an adjustable inner layer that can be added or removed, allowing users to modify the loft and firmness.

    This product launch is a strategic expansion of Mellow Sleep’s product portfolio, aligning with the company’s stated mission of using technology to improve sleep quality.

    For more information, visit the company’s official website at https://mellowsleep.com/.

    About Mellow Sleep: Mellow Sleep is a company dedicated to developing products intended to improve sleep health. Its focus is on the application of biomechanics, certified non-toxic materials, and user-centric design to create sleep solutions.

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    For more information about Mellow LLC, contact the company here:

    Mellow LLC
    Jay Yue
    9293555134
    dreamteam@mellowsleep.com
    8 The Green, Dover, DE 19901

  • Go Industries Expands Offerings With New Winch-Ready Grille Guard for Trucks

    Go Industries Expands Offerings With New Winch-Ready Grille Guard for Trucks

    Go Industries Inc., a truck equipment manufacturer, has announced a new addition to its product lineup. The company expanded its range of grille guards to include commercial-grade systems with integrated winch capabilities. This new product aims to meet the diverse demands of its clients, reflecting Go Industries’ ongoing commitment to creating products that improve the function and protection of vehicles.

    Go Industries Inc. is a manufacturer of law enforcement equipment and custom manufacturing solutions, operating since 1978. The company is based in Richardson, Texas, with a warehouse also in Clifton, TX. All products are made in the USA.

    winch grille guard for trucks

    The introduction of the winch grille guard for trucks marks an important development for the company. This system stands out due to its modular design, allowing users to add a winch carrier and brush guards. It’s built with durability in mind, featuring 5/16 laser-cut steel uprights and 2.5-inch 16-gauge steel cross tubes. The design ensures that the system can withstand tough conditions, providing reliable protection for truck enthusiasts and professionals.

    A representative of Go Industries expressed their enthusiasm for the launch, saying, “The launch of this commercial-grade integrated winch grille guard system is an exciting step forward for Go Industries. We have focused on creating a product that not only provides unmatched protection but can also be customized to meet the specific needs of our customers. Our grille guard systems are durable and customizable, and they underscore our dedication to maintaining high standards of quality and craftsmanship.”

    The development of the grille guard system pays significant attention to ease of installation. Each system includes custom heavy-duty mounting brackets designed for maximum strength, catering to the practical needs of customers. Additionally, optional brush guards provide extra protection for headlights against debris and off-road brush. The system also offers 9.5 or 16.5 winch carrier options, adding to its versatility for various uses.

    A three-year warranty backs each grille guard. This warranty covers materials, workmanship, and finish. Proudly made in the USA, these products are locally manufactured and with high-quality standards.

    Go Industries doesn’t only focus on grille guards. The company offers a wide array of truck accessories, including medium-duty grille guards, pro series bumpers, airflow tailgates, headache racks, mud flaps, and steps. These products deliver comprehensive solutions that blend practical enhancements with aesthetic appeal.

    The representative of Go Industries continued, “Our dedication to enhancing vehicle functionality while ensuring added protection is central to everything we produce. We are proud to expand our offerings with the new commercial-grade winch grille guard systems. This addition reinforces our capability to deliver the most practical and robust solutions for truck enthusiasts and professionals alike.”

    Beyond truck-specific products, Go Industries serves the law enforcement community by providing specialized equipment for Chevrolet, Dodge, and Ford vehicles. These products, which include skid plates and other necessary accessories, are designed to enhance the safety and utility of law enforcement vehicles.

    Furthermore, Go Industries offers custom manufacturing options, allowing customers to tailor products to their distinct needs. Customization allows the company to meet diverse customer demands and stay customer-oriented.

    Go Industries continues to grow and innovate its offered services and products. For more details on the new winch grille guard for trucks and other products, interested individuals should visit the company’s website.

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    For more information about Go Industries Inc, contact the company here:

    Go Industries Inc
    Go Industries
    800-527-4345
    sales@goindustries.com
    Go Industries Inc
    420 N Grove Rd
    Richardson, TX 75081

    Welcome to Go Industries | Truck Accessories | Law Enforcement | Custom Manufacturing

  • Promising Phase I Results for DO-2 MET Kinase Inhibitor Being Presented at World Conference on Lung Cancer 2025 in Barcelona

    Promising Phase I Results for DO-2 MET Kinase Inhibitor Being Presented at World Conference on Lung Cancer 2025 in Barcelona

    Liège, Liège – September 08, 2025 – (PRESS ADVANTAGE) –

    DO-2 is a Best in Class MET kinase inhibitor that completed enrolling a Phase 1 dose escalation study.

    Tumour shrinkage is observed in 100% of MET exon 14 skip NSCLC patients without additional oncogenic drivers, at doses that achieved preclinically defined thresholds.

    DO-2 has a very good safety profile with minimal peripheral oedema and clean safety profile compared to competitors.

    Liège, Belgium, September 9, 2025 – DeuterOncology, a clinical-stage biotech company focused on developing best-in-class deuterated cancer therapies, is announcing compelling safety, pharmacokinetic and efficacy results from its ongoing Phase I dose escalation study of DO-2, a novel deuterated MET tyrosine kinase inhibitor. The results are being presented at the World Conference on Lung Cancer (WCLC) 2025 in Barcelona (Abstract ID-2859).

    The Phase I study enrolled 29 patients (26 RECIST 1.1 evaluable) with advanced solid tumours harbouring any known driver alterations, with 86% having non-small cell lung cancer (NSCLC). The study’s primary findings demonstrate that DO-2 treated patients showed a remarkable 100% Disease Control Rate (DCR) and saw tumour shrinkage in 100% of MET exon 14 skip mutation-positive NSCLC patients without alternative oncogenic drivers and reached efficacious drug exposures (10/10 patients). RECIST 1.1 Partial responses (>30% reduction) were observed in 2 out of these 10. Importantly, the study showed a markedly improved safety profile compared to approved MET inhibitors, with only one patient (5%) experiencing grade 1 peripheral oedema versus 68-82% seen with other agents in this class.

    “These results represent a significant advancement in MET-targeted therapy,” said Dr. Cecilia Ahlin, CMO of DeuterOncology. “Our deuteration strategy has successfully enhanced drug exposure while maintaining efficacy, but most importantly, we’ve achieved this without the debilitating peripheral oedema that forces many patients to discontinue current MET inhibitors —symptoms that can severely limit daily activities such as walking, dressing, or cooking. This addresses a critical unmet medical need for cancer patients.”

    The study’s key findings include:

    Superior Safety Profile: Only 1 patient (5%) experienced peripheral oedema (grade 1) compared to 68-82% with approved competitors. No grade 3 or 4 peripheral oedema observed versus ~17% in approved competitors.

    Enhanced Pharmacokinetics: Deuteration increased plasma exposure compared to the non-deuterated parent compound, enabling once-daily dosing at 60mg with food, versus 450-800mg daily with approved competitors.

    Promising Efficacy: 100% disease control rate (DCR) and 2 Partial responses in treatment-naïve and previously treated MET exon 14 skip NSCLC patients without known resistance mechanisms and achieved efficacious exposures. One patient maintaining stable disease for more than 20 months.

    Excellent Tolerability: Only two grade 3 treatment-related adverse events (fatigue and reversible creatinine increase) were observed across all dose levels.

    Dr. Hans Prenen, Principal Investigator at University Hospital Antwerp (UZA), commented: “The clinical data for DO-2 are very encouraging. The fact that we’re seeing robust antitumour activity with minimal peripheral oedema represents a potential game-changer for MET-driven lung cancer patients, who currently face difficult treatment tolerability issues with existing therapies.”

    The study confirms DeuterOncology’s hypothesis that continuous 24/7 MET inhibition is not required for efficacy but is responsible for the class-effect toxicity of peripheral oedema. DO-2’s unique biochemical and pharmacokinetic profile allows for effective target engagement while providing recovery periods that minimize on-target toxicities.

    Based on these promising Phase I results, DeuterOncology has initiated an expansion cohort in selected first-line MET exon 14 skip NSCLC patients to further validate the safety and efficacy of the 60mg once-daily regimen.

    About MET-Driven Lung Cancer

    Lung cancer remains the most common form of cancer worldwide, affecting approximately 2.2 million individuals annually. MET exon 14 skipping mutations occur in ~3% of NSCLC patients—equating to an estimated 60,000–70,000 new cases worldwide annually—and represent a validated therapeutic target. However, current approved MET inhibitors suffer from high rates of peripheral oedema (>50% of patients), leading to frequent dose reductions, treatment interruptions, and discontinuations that compromise patient outcomes.

    About DeuterOncology

    DeuterOncology is a clinical-stage biotech company focused on developing deuterated kinase inhibitors as best-in-class targeted cancer therapies. The company’s lead candidate, DO-2, is a novel deuterated MET kinase inhibitor designed to overcome the tolerability limitations of current MET-targeted therapies while maintaining superior efficacy. Headquartered in Liège, Belgium, DeuterOncology was founded in 2020 by Dr. Timothy Perera and collaborates with a global expert network of partners to bring innovative cancer solutions to patients worldwide.

    For more information about DeuterOncology’s research, please visit www.deuteroncology.com

    Contact Information: Dr Timothy Perera, CEO
    e-mail: tperera@deuteroncology.com
    Phone: +32473558353

    Details of the poster presentation are as follow:

    Title: Preliminary Safety and PK of the MET-TKI DO-2 in Advanced Solid Tumors with MET Aberrations: Phase I Study Authors: Hans Prenen MD, PhD, Rachel Galot MD, PhD, Alexis Cortot MD, PhD, Aurélie Swalduz MD, PhD, Bernd Dekeyser MD, Peter de Bruijn PhD, Francois Zammit MD, JeanPascal Machiels MD, PhD, Brant Delafontaine MD, Sylvie Rottey MD, PhD, Ingrid Desar MD, PhD, Marthe Paats MD, PhD, Barend J. Sikkema3MD, , Florence Wastelin MSc, Cecilia Ahlin MD PhD, Timothy Perera PhD, Jaap Verweij MD, PhD, Carla van Herpen MD, PhD, Debbie G.J. Robbrecht MD, PhD

    Presenter: Timothy Perera

    Session date and time: 09 September 2025. 10.00AM

    Poster ID number: Abstract ID-2859. P3.18.66

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    For more information about DeuterOncology, contact the company here:

    DeuterOncology
    Dr Timothy Perera, CEO
    +32473558353
    tperera@deuteroncology.com
    DeuterOncology
    Afinis Business Centre,
    Clos Chanmurly 13,
    Liege 4000,
    Belgium

  • Go Industries Inc. Unleashes Winch Grille Guards for Front-End Truck Protection

    Go Industries Inc. Unleashes Winch Grille Guards for Front-End Truck Protection

    Go Industries Inc., a truck accessories and custom manufacturing company, is introducing a brand-new commercial-grade integrated winch grille guard system. This system is built for both strength and adaptability, catering to truck owners who need reliable front-end protection. Designed with practicality in mind, the grille guard system features a modular setup, which lets users add winch carriers and Brush Guards as needed.

    “We’re focused on delivering quality and versatility with our products,” says the CEO of Go Industries. “The launch of our commercial-grade integrated winch system fits with our mission to provide truck owners with the ability to customize their vehicle’s protection without skimping on strength or reliability.”

    winch grille guard

    The grille guard is made from solid 5/16 laser-cut steel uprights and 2.5-inch 16-gauge steel cross tubes. This robust construction means it can withstand road debris and obstacles in tough driving conditions. Owners can choose between 9.5 or 16.5 winch carriers, offering flexibility to meet different towing needs. Such customizable options allow worktruck winch owners to tailor their vehicle’s protection based on the specific challenges they might face on the road.

    Installation is made easier with heavy-duty mounting brackets included with each grille guard. These ensure a strong and simple setup. For extra protection, the optional Brush Guards enhance the vehicle’s lines while shielding headlights from debris or brush often encountered during off-road driving. Every product in this lineup carries a three-year warranty covering materials, craftsmanship, and finish quality.

    Since 1978, Go Industries has provided truck accessories with the unique needs of truck owners in mind. The company’s offerings include grille guards, heavy-duty headache racks, and bumper replacements, all showcasing their commitment to American-made quality. The winch grille guard system continues this tradition, giving vehicle owners confidence in their trucks’ capability to handle demanding conditions.

    In addition to their durable products, Go Industries embraces modern payment trends by accepting cryptocurrency. This move reflects their forward-thinking attitude, offering customers the convenience and security of today’s payment methods. By providing digital currency options, Go Industries aims to expand access to its products, meeting the evolving landscapes of commerce.

    A company spokesman added, “Items like the Go Industries Commercial Grade Winch System are crafted to tackle everyday challenges drivers face. We combine advanced manufacturing techniques with durable materials to provide accessories that not only meet but exceed industry standards.”

    Besides the winch grille guard system, Go Industries also offers various services to meet customer needs. Their lineup includes custom manufacturing options, allowing clients to request specific designs that suit their requirements.

    Based in Richardson, Texas, Go Industries serves a wide range of customers in the truck accessories and custom manufacturing sectors.

    For more details about the worktruck winch grille guard system and other products, customers are encouraged to visit Go Industries’ website. The website also provides detailed information on specialized equipment for law enforcement vehicles and an option to get a quote for custom manufacturing services.

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    For more information about Go Industries Inc, contact the company here:

    Go Industries Inc
    Go Industries
    800-527-4345
    sales@goindustries.com
    Go Industries Inc
    420 N Grove Rd
    Richardson, TX 75081

    Welcome to Go Industries | Truck Accessories | Law Enforcement | Custom Manufacturing